Projects - Multiple Sclerosis

Protein

Description

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PARP is believed to play a role in in neurodegenerative diseases. The details are complex and not fully understood. One major component of inflammatory neuronal damage is the transformation of microglia cells into activated immunoeffector cells and their migration towards the sites of injury, where they produce large amounts of toxic cytokines and oxygen radicals. PARP also regulates the production of certain proteins.

PARP also has a potential therapeutic role in cancer treatment. It facilitates the repair of DNA strand breaks and its inhibition may make radiotherapy and chemotherapy more effective when resistance occurs.

We expect job times of about 8-20 hours and above average hit rates.

Interleukin-12 (IL-12) belongs to the cytokine class of proteins and is crucial for the generation of immunity to intracellular pathogens. It is known to stimulate production and enhance the activity of natural killer cells and T cells, and to induce production of interferon. It is important in preventing infection by intracelluar bacteria and parasites. IL-12 also contributes to various immunopathological conditions, so understanding its role may lead to new therapies for rheumatoid arthritis, multiple sclerosis and other autoimmune diseases.

Interleukin-12B (IL-12B) belongs to the cytokine class of proteins and is crucial for the generation of immunity to intracellular pathogens. It is known to stimulate production and enhance the activity of natural killer cells and T cells, and to induce production of interferon. It is important in preventing infection by intracelluar bacteria and parasites. IL-12B also contributes to various immunopathological conditions, so understanding its role may lead to new therapies for rheumatoid arthritis, multiple sclerosis and other autoimmune diseases. This query differs from 1f42-q1 because we are targetting a site on the beta subunit.

Interleukin-12B (IL-12B) belongs to the cytokine class of proteins and is crucial for the generation of immunity to intracellular pathogens. It is known to stimulate production and enhance the activity of natural killer cells and T cells, and to induce production of interferon. It is important in preventing infection by intracelluar bacteria and parasites. IL-12B also contributes to various immunopathological conditions, so understanding its role may lead to new therapies for rheumatoid arthritis, multiple sclerosis and other autoimmune diseases. This query targets a variant of the site used in 1f42-q2 .

Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and nerve axon loss. The immune response is responsible for the degradation of the protective myelin sheath around the spinal cord. This involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG) located at the surface of CNS myelin. This is the first of a short series of queries where we seek small molecules which might inhibit the immune responsible which would halt the progress of the disease.

Test jobs for this query gave relatively few hits and took less time than average jobs.

Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and nerve axon loss. The immune response is responsible for the degradation of the protective myelin sheath around the spinal cord. This involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG) located at the surface of CNS myelin. This is the second of a short series of queries where we seek small molecules which might inhibit the immune responsible which would halt the progress of the disease. The series target different sites of the same protein.

Test jobs for this query took longer than typical jobs giving average numbers of hits.

Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and nerve axon loss. The immune response is responsible for the degradation of the protective myelin sheath around the spinal cord. This involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG) located at the surface of CNS myelin. This is the second of a short series of queries where we seek small molecules which might inhibit the immune responsible which would halt the progress of the disease. The series target different sites of the same protein.

Test jobs for this query took less time than typical jobs giving few hits.

Tumor Necrosis Factor (also known as cachetin) is an inflammatory mediator that is relevant to several autoimmune diseases and bacterial infection. In this query we are targetting TNF Receptor 1 (also known as p55) which is thought to be associated with the inflammatory response. Suppression of such inflammatory responses would be expected to benefit suffers of Multiple Sclerosis. TNF's name originates from the observation over 100 years ago causing beneficial inflammatory effects resulting in tumour cell death in terminally ill cancer patients.